Data/hora: 05/06/2024 09:00:41

Provedor de dados: | 60
País: | Brazil
Título: | Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
Autores: | Huri,Hasniza Zaman; Huey,Chua Chew; Mustafa,Norasyikin; Mohamad,Nor Fadhilah; Kamalden,Tengku Ain.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Type 2 Diabetes Mellitus; Anti-diabetic agents; Microvascular complication; Diabetic macula edema; Diabetic retinopathy; Malaysia.
Resumo: | Abstract The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200608
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902018000217484
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.54 n.2 2018
Fonte: | info:eu-repo/semantics/openAccess