Data/hora: 06/06/2024 00:46:02

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Cyclodextrins and ternary complexes: technology to improve solubility of poorly soluble drugs	
Autores: 	Miranda,Janisse Crestani de; Martins,Tércio Elyan Azevedo; Veiga,Francisco; Ferraz,Humberto Gomes.	
Data: 	2011-12-01	
Ano: 	2011	
Palavras-chave: 	Cyclodextrins; Ternary complexes; Drugs/complexation; Water-soluble polymers/use; Drugs/solubility; Inclusion complexe.	
Resumo: 	Cyclodextrins (CDs) are cyclic oligosaccharides composed of D-glucopyranoside units linked by glycosidic bonds. Their main property is the ability to modify the physicochemical and biological characteristics of low-soluble drugs through the formation of drug:CD inclusion complexes. Inclusion complexation requires that host molecules fit completely or partially within the CD cavity. This adjustment is directly related to the physicochemical properties of the guest and host molecules, easy accommodation of guest molecules within the CD cavity, stoichiometry, therapeutic dose, and toxicity. However, dosage forms may achieve a high volume, depending on the amount of CD required. Thus, it is necessary to increase solubilization efficiency in order to use smaller amounts of CD. This can be achieved by adding small amounts of water-soluble polymers to the system. This review addresses aspects related to drug complexation with CDs using water-soluble polymers to optimize the amount of CD used in the formulation in order to increase drug solubility and reduce dosage form volume.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400003	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502011000400003	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.47 n.4 2011	
Fonte: 	info:eu-repo/semantics/openAccess