Data/hora: 05/06/2024 18:44:12

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Misoprostol and teratogenesis in neonates	
Autores: 	Silva,Mariana Beatriz Scabora da; Ferreira,Aline de Assis; Habr,Soraya Ferreira; Bernardi,Maria Martha.	
Data: 	2009-09-01	
Ano: 	2009	
Palavras-chave: 	Perinatal toxicology; Misoprostol; Malformations; Moebius syndrome; Abortion; Cytotec®.	
Resumo: 	This paper is focused in some aspects of maternal exposure to misoprostol during perinatal period, and the abortive and teratogenesis effects on the fetus. The causes of malformations were revised, taking into account chemical, physical and environmental factors as well as the interaction between them. There are evidences that the practice of abortion tripled in Southern and Northeastern Brazil in 15 years, and one of the most frequent forms of abortion is through the use of misoprostol. In Brazil, 1991, 288,700 women were hospitalized as a consequence of complications induced by abortion attempt with this medicine. This fact resulted in the ban of misoprostol across our country, by Decree 344/98 determined by the Health Ministry. The use of misoprostol requires special control and it is allowed only in hospitals, with supervision of the municipal health surveillance. Among the more severe problems affecting the non-aborted child is the injury on the central nervous system, which frequently results in the Moebius syndrome. This is a congenital and non-progressive paralysis of the VI and VII cranial nerves, frequently bilateral, which produces a unexpressive facial appearance and convergent Strabismus. Even banned in our country, abortion is illegally practiced, being deprived of proper knowledge about misoprostol teratogenic effects on the fetus as well as the risks involving mothers.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300005	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502009000300005	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.45 n.3 2009	
Fonte: 	info:eu-repo/semantics/openAccess