Data/hora: 01/06/2024 02:07:37

Provedor de dados: | 60
País: | Brazil
Título: | A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets
Autores: | Ogunjimi,Abayomi Tolulope; Alebiowu,Gbenga.
Data: | 2010-06-01
Ano: | 2010
Palavras-chave: | Coprocessing; Neem gum; Microcrystalline cellulose; Binder; Tensile strength; Brittle fracture index; Paracetamol.
Resumo: | A 2³ factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), concentration of binder (C) and the applied pressure (P) on two mechanical properties, namely, tensile strength (TS) and brittle fracture index (BFI), of paracetamol tablets. The factorial design was also used to study the quantitative effects of coprocessing of binders on the mechanical properties. The results obtained from this study suggest that the nature (i.e. plastic/elastic) and ratio of binders coprocessed together alter the influence of C and P on TS and BFI.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200006
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502010000200006
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.46 n.2 2010
Fonte: | info:eu-repo/semantics/openAccess