Data/hora: 11/06/2024 10:56:02

Provedor de dados: 	60	
País: 	Brazil	
Título: 	A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties	
Autores: 	Montaña,Jorge Andrés; Perez,León Darío; Baena,Yolima.	
Data: 	2018-01-01	
Ano: 	2018	
Palavras-chave: 	Interpolyelectrolyte complex; Pharmacotechnical properties; Dexibuprofen; Controlled release; Hydrophillic matrix.	
Resumo: 	ABSTRACT Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200620	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/s2175-97902018000217183	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.54 n.2 2018	
Fonte: 	info:eu-repo/semantics/openAccess