Data/hora: 05/06/2024 10:36:00

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction	
Autores: 	Vinagre,Anapaula Sommer; Rönnau,Ângela Della'Santa Rubio Origuella; Pereira,Sabrina Francisco; Silveira,Lídia Uliano da; Wiilland,Elenir de Fátima; Suyenaga,Edna Sayuri.	
Data: 	2010-06-01	
Ano: 	2010	
Palavras-chave: 	Campomanesia xanthocarpa/pharmacognosy; Diabetes Mellitus/experimental study; Hypoglycemic plant; Histology; Carbohydrate/metabolism; Lipid/metabolism.	
Resumo: 	The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200002	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502010000200002	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.46 n.2 2010	
Fonte: 	info:eu-repo/semantics/openAccess