Data/hora: 09/06/2024 03:45:17

Provedor de dados: 	60	
País: 	Brazil	
Título: 	In vitro characterization and in vivo performance of mefenamic acid-sodium diethyldithiocarbamate based liposomes	
Autores: 	Jarrar,Qais Bashir; Hakim,Muhammad Nazrul; Cheema,Manraj Singh; Zakaria,Zainul Amiruddin.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	Mefenamic acid; Liposomes-characterization; Sodium diethyldithiocarbamate; Extrapyramidal symptoms; Carrageenan.	
Resumo: 	Mefenamic acid (MFA) is a hydrophobic drug with low dissolution rate. This study aimed to develop stable and reproducible aqueous formulations of MFA using liposomes as drug carriers. The drug entrapment, particles size and drug release profiles, and stability and reproducibility of the liposomes were determined. In addition, the maximum tolerated dose (MTD) was determined in rats via the oral and intraperitoneal routes of administration. Also, the anti-inflammatory efficacy of these liposomes was evaluated using carrageenan-induced paw edema model in rats. MFA-DDC based liposomes demonstrated a drug entrapment efficacy of 93.6%, particles size of 170.9 nm, and polydispersity index of 0.24 which were not statistically affected when stored in room and refrigerated temperatures for at least 4 weeks. The MTD of the intraperitoneally administrated MFA-loaded liposomes was 20 mg MFA/kg, whereas for those of oral administrations, it was up to 80 mg MFA/kg. Intraperitoneal dose (80 mg MFA/kg) of MFA-DDC liposomes induced extrapyramidal symptoms associated with significant elevation in serum potassium and muscle enzymes. Moreover, significant inhibition of paw edema was demonstrated by the oral and intraperitoneal routes. These findings suggest that MFA-DDC based liposomes are an effective formulation of MFA and recommend the use of bioequivalence assessments with commercial formulations.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100553	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/s2175-97902019000117870	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.55 2019	
Fonte: 	info:eu-repo/semantics/openAccess