Data/hora: 01/06/2024 00:51:58

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Sustained virological response to treatment of chronic hepatitis C with peginterferon alfa and ribavirin	
Autores: 	Rosa,Junior André da; Blatt,Carine Raquel; Peres,Kaite Cristiane; Storb,Bernd Heinrich; Silva,Rochele; Farias,Mareni Rocha.	
Data: 	2012-06-01	
Ano: 	2012	
Palavras-chave: 	Hepatitis C; Hepatitis C Chronic; Effectiveness; Interferon alfa-2a; Interferon alfa-2b.	
Resumo: 	This study aimed to evaluate the rate of sustained virological response (SVR) and the clinical and treatment characteristics of patients with chronic hepatitis C (CHC). A retrospective uncontrolled cohort study was conducted among patients who received treatment for CHC between 2005 and 2008 attended at the Center for the Application and Monitoring of Injectable Medications, in Florianopolis, SC, Brazil. The inclusion criteria were: patients over 18 years of age, with a confirmed diagnosis of chronic hepatitis C according to Brazilian guidelines, treated with PEG-IFN alfa-2a or 2b associated with RBV. A total of 188 patients were included in the study: 70% men, 59% genotype 1, 27% coinfected with HIV, 31% with cirrhosis. The SVR rate, calculated by probability theory, was determined as 26% (max=57.4% and min=12.8%) and the intention to treat was 12.8%. Associations between Sustained Virological Response (SVR) and the variables sex (p=0.017), age (p=0.003), genotype (p=0.648) and cirrhosis (p=0.275), were determined in the bivariate analysis and only sex and age were significantly associated with SVR. The SVR rate was considered low, which can be partially explained by patients' unfavorable pretreatment characteristics.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200002	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502012000200002	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.48 n.2 2012	
Fonte: 	info:eu-repo/semantics/openAccess