Data/hora: 01/06/2024 02:04:54

Provedor de dados: | 60
País: | Brazil
Título: | Appraisal of acute oral toxicity of glucuronoxylan hydrogel from Mimosa pudica seeds
Autores: | Muhammad,Gulzar; Hussain*,Muhammad Ajaz; Ashraf,Muhammad Umer; Naeem-ul-Hassan,Muhammad; Bukhari,Syed Nasir Abbas.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Glucuronoxylan; Acute toxicity; Histopathology; Toxicology; Mimosa pudica.
Resumo: | Glucuronoxylan hydrogel (GXH) isolated from M. pudica seeds was assessed for acute toxicology in albino mice that were alienated into four groups. Three groups, i.e., II, III and IV received GXH at a dose of 1, 2 and 5 g/kg, respectively while group I was retained untreated and provided routine diet. After administering GXH, mice were examined for vomiting, diarrhea, allergy and tremors for 8 h. All animals were carefully observed for food and water consumption at 1, 2, 3, 7 and 14 day after administering GXH. At the end of studies, blood samples were drawn for investigation of hematological and biochemical parameters. All animals were sacrificed, relative body weight of vital organs was calculated and their histopathology was studied. It was concluded that there was insignificant difference in body weight, behavioral pattern, food and water intake among treated and control groups. Haematology and biochemistry of blood samples from all groups were found analogous. Histopathological evaluation of vital body organs exhibited no lesions in all groups. Ocular, cardiac and dermal safety of GXH was also established on albino rabbits.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300619
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902018000317579
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.54 n.3 2018
Fonte: | info:eu-repo/semantics/openAccess