Data/hora: 11/06/2024 09:13:34

Provedor de dados: | 60
País: | Brazil
Título: | Thermodynamic study of the solubility of ibuprofen in acetone and dichloromethane
Autores: | Aragón,Diana Marcela; Rosas,Jaiver Eduardo; Martínez,Fleming.
Data: | 2010-06-01
Ano: | 2010
Palavras-chave: | Ibuprofen; Solubility; Transfer; Solution thermodynamics; Organic solvents.
Resumo: | Thermodynamic functions, Gibbs energy, enthalpy and entropy for the solution processes of ibuprofen (IBP) in acetone and dichloromethane (DCM) were calculated from solubility values obtained at temperatures ranging from 293.15 K to 313.15 K. The respective thermodynamic functions for mixing and solvation processes as well as the activity coefficients for the solute were calculated. IBP solubility was high and proved similar in both solvents but was greater in DCM than acetone. In addition, the thermodynamic quantities for the transfer process of this drug from cyclohexane to the organic solvents were also calculated in order to estimate the contributions of hydrogen-bonds or of other dipolar interactions. The results were discussed in terms of solute-solvent interactions.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200009
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502010000200009
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.46 n.2 2010
Fonte: | info:eu-repo/semantics/openAccess