Data/hora: 01/06/2024 02:25:19

Provedor de dados: 	60	
País: 	Brazil	
Título: 	In vitro antimicrobial efficacy of a fixed-dose combination of RHZE against M. tuberculosis	
Autores: 	Agertt,Vanessa Albertina; Bonez,Pauline Cordenonsi; Mizdal,Caren Rigon; Rossi,Grazielle Guidolin; Flores,Vanessa da Costa; Campos,Marli Matiko Anraku de.	
Data: 	2016-09-01	
Ano: 	2016	
Palavras-chave: 	Mycobacterium tuberculosis/treatment/drug combination; Mycobacterium tuberculosis/drug resistance; Mycobacterium tuberculosis/susceptibility/fixed dose combination.	
Resumo: 	ABSTRACT The use of drugs in fixed-dose combination (FDC) is now recommended by the World Health Organization (WHO) due to the emergence of multidrug-resistant strains of Mycobacterium tuberculosis. FDC uses different drugs against tuberculosis (TB) in a single tablet for phase-intensive therapeutic intervention. This therapy aims to optimize treatment, to prevent inappropriate use of drugs, and to prevent the emergence of new resistant strains. This study aims to evaluate the susceptibility of clinical isolates of M. tuberculosis against rifampicin, isoniazid, ethambutol, and pyrazinamide. The antimicrobials were tested separately and in associations according to FDC. This was used for broth microdilution method, which was compared to the proportions method previously considered as the gold standard. In antimicrobials testing alone, several strains were resistant to one, two, or three drugs. However, when applied to association of drugs in FDC, there was no antimicrobial resistance. The results strengthen the FDC's concept, which aims to unite the four anti-TB drugs to combat bacterial resistance.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300575	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/s1984-82502016000300022	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.52 n.3 2016	
Fonte: 	info:eu-repo/semantics/openAccess