Data/hora: 06/06/2024 00:39:10

Provedor de dados: 	65	
País: 	Brazil	
Título: 	Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints	
Autores: 	Moreira,Juliana Junqueira; Coelho,Joyce Martins; Machado,Thais Sodré Lima; Morais,Ana Paula Lopes; Michelacci,Yara Maria; Baccarin,Raquel Yvonne Arantes.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	Chondroitin sulfate; Horse; Glucosamine; Osteoarthritis; Synovial fluid.	
Resumo: 	ABSTRACT:  Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed. Concerning the SF, CS concentration increased after the end of the treatment and returning to baseline afterwards, while HA and PGE2 concentrations did not change. Despite the systemic distribution, oral supplementation of CS/GlcNfor 25 days was insufficient as an anti-inflammatory support. However, it is possible to infer that there was an anabolic effect upon cartilage matrix.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602	
Editor: 	Universidade Federal de Santa Maria	
Relação: 	10.1590/0103-8478cr20180247	
Formato: 	text/html	
Fonte: 	Ciência Rural  v.49 n.9 2019	
Fonte: 	info:eu-repo/semantics/openAccess