Data/hora: 09/06/2024 14:37:14

Provedor de dados: | 65
País: | Brazil
Título: | P53 gene: major mutations in neoplasias and anticancer gene therapy
Autores: | Lima,Caroline Rocha de Oliveira; Rabelo,Rogério Elias; Vulcani,Valcinir Aloísio Scalla; Cardoso,Lorena Damasio; Sousa,Nicaelle Luan de Moura; Moura,Veridiana Maria Brianezi Dignani de.
Data: | 2012-05-01
Ano: | 2012
Palavras-chave: | Mutations; Neoplasia; Gene therapy; P53.
Resumo: | The p53 gene encodes a protein that has molecular weight of 53kD and is also called p53 protein, being constantly studied for its classic concept of "genome guardian". This gene plays a range of essential functions to ensure the cell cycle control, in addition to playing a central role in carcinogenesis. With respect to neoplasias, it prevents the neoplastic transformation through three intricate mechanisms. Depending on the extent of the mutation, different responses may be sent by p53 and those range since the disruption of the cell cycle, the correction of the mutation through the activation of repair proteins or still, the induction of senescence or cell death by apoptosis. This review aims to address the structural and functional aspects of the p53 gene and protein, and also reaffirm their participation in the carcinogenesis control, approaching their major mutations and the anticancer gene therapy involving this gene.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782012000500014
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/S0103-84782012000500014
Formato: | text/html
Fonte: | Ciência Rural  v.42 n.5 2012
Fonte: | info:eu-repo/semantics/openAccess