Data/hora: 05/06/2024 10:32:52

Provedor de dados: | 65
País: | Brazil
Título: | Systemic and local antibodies induced by an experimental inactivated vaccine against bovine herpesvirus type 1
Autores: | Cilento,Maria do Carmo; Pituco,Edviges Maristela; Jordão,Ricardo Spacagna; Ribeiro,Cláudia Pestana; Marchiori Filho,Moacir; Montassier,Hélio José.
Data: | 2011-02-01
Ano: | 2011
Palavras-chave: | BoHV-1; Immunoglobulin isotypes; Experimental vaccine.
Resumo: | An experimental inactivated vaccine against bovine herpesvirus-1 (BoHV-1) was produced aiming to evaluate the systemic and local antibody responses in 12 seronegative heifers, after vaccination and revaccination. Serum samples were submitted to virus neutralization assay and to ELISA test for detection of IgG1 and IgG2 isotypes. Nasal secretion samples were submitted to the same ELISA test for detection of IgG1 and IgG2 isotypes. The results showed that moderate to high neutralizing titres and IgG1 and IgG2 antibody responses were induced after the second vaccination in the serum and in nasal secretions up to 114 days post vaccination. IgG2 antibodies were the prevalent isotype for most of the post-vaccination period. The results indicate that BoHV-1 experimental inactivated vaccine elicited potentially protective IgG1 and IgG2 antibody levels, both in the systemic and mucosal compartments.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782011000200021
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/S0103-84782011000200021
Formato: | text/html
Fonte: | Ciência Rural  v.41 n.2 2011
Fonte: | info:eu-repo/semantics/openAccess