Data/hora: 01/06/2024 13:42:33

Provedor de dados: | 65
País: | Brazil
Título: | Dextran iron in anemic lambs: effects on reticulocytosis and free radical production
Autores: | Rocha,Ricardo Xavier da; Bondan,Carlos; Marinho,Roberto; Lopes,Sônia Terezinha dos Anjos; Cecim,Marcelo.
Data: | 2007-10-01
Ano: | 2007
Palavras-chave: | TBARS; NPTH; Lambs; Free-radicals; Iron.
Resumo: | Anemia due to worm infection is a major cause of loss in the sheep industry, due to deaths, drop in average daily gains and long recovery time following treatment. The present experiment was aimed at evaluating the oxidative status and the recovery of red blood cell (RBC) profile in lambs with induced anemia by bleeding, treated or not with dextran iron. Ten ram lambs 5 to 7 months old were used. Blood samples were drawn every other day and when reached packed cell volume (PCV) of 15% were randomly allocated (day zero) to one of the experimental groups. Treated group received a single dose of 25mg per kg body weight of a commercial formulation of dextran iron, the control group received no treatment. Blood samples were taken on days 0, 7, 14, and 21 after treatment. On days 7 an 21 treated animals presented higher thyobarbituric acid reactive species (TBARS) values, reduced non-protein thiol groups (NPTH) levels were found in the treated group on days 7, 14 and 21. Erythrocyte membrane resistance to osmotic challenge was improved on day 7 in treated animals. Recovery to normal values for the RBC profile was faster in the treated group with significant differences starting on day 7. It was conclude that althouth the iron treatment increased the oxidative stress, it also accelerated recovery of the hematological profile. Moreover, it did not increase hemolysis in anemic blood by the action of oxygen reactive species upon biological membranes.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000500019
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/S0103-84782007000500019
Formato: | text/html
Fonte: | Ciência Rural  v.37 n.5 2007
Fonte: | info:eu-repo/semantics/openAccess