Data/hora: 02/06/2024 10:45:03

Provedor de dados: | 65
País: | Brazil
Título: | Immunomodulatory action of jacalin from Artocarpus integrifolia and mannoprotein from Saccharomyces uvarum on the humoral immunity of laying hens
Autores: | Silva,Marco Aurélio Chiara; Silva,Miriele Caroline da; Pinheiro,João Waine; Castro-Goméz,Raul Jorge Hernan; Murakami,Alice Eiko; Loyola,Wagner; Venancio,Emerson José.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | Artocarpus integrifolia; Chickens; IgY; Jacalin; Mannoprotein; Humoral immune response; Saccharomyces uvarum.
Resumo: | ABSTRACT: Advances in the fields of glycobiology and immunology have provided many insights into the role of carbohydrate-protein interactions in the immune system. Jacalin of Artocarpus integrifolia (JCA) and structural mannoprotein of Saccharomyces uvarum (MPS) are molecules with immunomodulatory properties. JCA is an IgA human lectin binding molecule that causes the mitogenic stimulation of immune cells, production of cytokines, chemotaxis, and activation of leukocytes. Studies on the immunomodulatory properties of JCA and MPS in mammals and fish suggest that they have an action on antibody production. The aim of this study was to investigate the possible action of JCA and MPS on the production of specific antibodies in laying hens. For this, laying hens were inoculated with an intra abdominal injection of sheep red blood cells (SRBC) with either JCA (0.075 µg, 0.75 µg, and 7.5 µg) or MPS (20 µg and 100 µg). Levels of anti-SRBC antibodies of the IgY, IgM, and IgA classes were evaluated by ELISA. Results showed that JCA and MPS have immunomodulatory effects on levels of anti-SRBC IgM, IgA, and IgY. An immunostimulatory effect of JCA was observed in primary immune response on anti-SRBC IgY, while an inhibitory effect of JCA and MPS was observed in secondary immune response on the production of IgM and IgA anti-SRBC. These results suggested that MPS and JCA have immunomodulatory effects on antibody production and could be used in future studies on humoral immune response in poultry.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782020000400453
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/0103-8478cr20190700
Formato: | text/html
Fonte: | Ciência Rural  v.50 n.4 2020
Fonte: | info:eu-repo/semantics/openAccess