Data/hora: 06/06/2024 05:44:45

Provedor de dados: | 65
País: | Brazil
Título: | Different leaf extracts from Brunfelsia uniflora in mice
Autores: | Carvalho,Ciro José Sousa de; Melo,Marília Martins; Michell,Ana Flávia Ribeiro Machado; Torres,Bruno Benetti Junta; Riet-Correa,Franklin; Guedes,Roberto Maurício Carvalho; Ferraz,Vany Perpetua; Soto-Blanco,Benito; Silva,Silvana Maria Medeiros de Sousa.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Toxicity; Alkaloids; Saponins; Flavonoids; Brunfelsia; Solanaceae.
Resumo: | ABSTRACT: In Brazil, at least 16 poisonous plant species can affect the central nervous system of livestock. Recently in the state of Piauí, Northeastern Brazil, Brunfelsia uniflora was reported as a cause of nervous signs in donkeys, cattle, and small ruminants. In order to assess the toxicity of B. uniflora extracts, 20 Swiss mice were distributed into four groups (n=5) receiving by gavage alkaloids, flavonoids, saponins, or saline (control group). After administration of the extracts in a single dose (5g kg-1), all mice were observed daily for clinical signs. Mice that received the extracts showed moderate to severe clinical signs, including piloerection, vocalization, and seizures. All mice dosed with saponins died between 10 and 20min after administration. Serum biochemical evaluation of animals that received saponins revealed slight increases in total protein levels and decreased magnesium and chlorite levels. In conclusion, saponins of B. uniflora leaves induced acute toxic neurological effects and death in mice.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000100552
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/0103-8478cr20170246
Formato: | text/html
Fonte: | Ciência Rural  v.48 n.1 2018
Fonte: | info:eu-repo/semantics/openAccess