Data/hora: 06/06/2024 03:23:19

Provedor de dados: | 65
País: | Brazil
Título: | Wobbly syndrome in an Africa pygmy hedgehog (Atelerix albiventris): neuropathological and immunohistochemical studies
Autores: | Oliveira,Letícia Batelli de; Moreira,Matheus Vilardo Lóes; Santos,Willian Henrique de Magalhães; Stuart,Líslie Caroline Oliveira; Castro,Maria Dolors Pi; Balle,Martí Pumarola; Ecco,Roselene.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | Central nervous system; Degenerative disease; Myelopathy; Vacuolation; Histopathology.
Resumo: | ABSTRACT:  A three-year-old female African pygmy hedgehog (Atelerix albiventris), born and domiciled in Brazil, presented apathy, prostration, and difficulty to stay standing. Its parents were siblings but did not present clinical signs related to this condition. As its clinical condition worsened, the animal was euthanized and referred for necropsy. No gross lesions were found in the central nervous system (CNS). Histologically, there was vacuolation with axonal degeneration in the white matter of the CNS and in peripheral nervous tissue. The Kluver-Barrera (KB) stain confirmed demyelination in vacuolated areas. Immunohistochemistry using several neural markers confirmed astrocytosis and microgliosis associated with vacuolated areas. In addition, there was a mild decrease in the immuno intensity of myelin proteolipid protein (PLP) in these areas. These results suggest a genetic origin of the present demyelination, which resulted in the wobbly syndrome described in this report.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000100550
Editor: | Universidade Federal de Santa Maria
Relação: | 10.1590/0103-8478cr20180742
Formato: | text/html
Fonte: | Ciência Rural  v.49 n.1 2019
Fonte: | info:eu-repo/semantics/openAccess