Data/hora: 07/06/2024 08:32:43

Provedor de dados: 	65	
País: 	Brazil	
Título: 	Identification of multi-drug resistance gene (MDR1) in equine ileum	
Autores: 	Natalini,Cláudio Corrêa; Linardi,Renata Lehn.	
Data: 	2006-02-01	
Ano: 	2006	
Palavras-chave: 	Molecular biology; Opioids; Equine; Gene; MDR1; ABCB1.	
Resumo: 	P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100048	
Editor: 	Universidade Federal de Santa Maria	
Relação: 	10.1590/S0103-84782006000100048	
Formato: 	text/html	
Fonte: 	Ciência Rural  v.36 n.1 2006	
Fonte: 	info:eu-repo/semantics/openAccess