Data/hora: 01/06/2024 02:55:16

Provedor de dados: 	65	
País: 	Brazil	
Título: 	Autologous bone marrow transplantation in a dog with lymphoma: a clinical study	
Autores: 	Cápua,Maria Luísa Buffo de; Coleta,Flávia Eiras Dela; Miotto,Mariana Rodrigues; Calazans,Sabryna Gouveia; Godoy,Aline Vieira; Nakage,Ana Paula Massae; Lisbão,Carolina Bonduki Sales; Daleck,Carlos Roberto; Santana,Aureo Evangelista.	
Data: 	2009-04-01	
Ano: 	2009	
Palavras-chave: 	Canine; Cutaneous lymphoma; Autologous bone marrow transplant; Chemotherapy.	
Resumo: 	The objective of this study is to provide the first report of bone marrow transplantation (BMT) in dogs in Brazil. A Rottweiler with cutaneous lymphoma was submitted to a twelve-week Madison-Wisconsin chemotherapy protocol followed by autologous bone marrow transplantation. For this, 10mL kg-1 of bone marrow was collected simultaneously from both iliac crests and cryopreserved in a freezer at -80°C. The conditioning step was performed by administering cyclophosphamide by intravenous route at 400mg m-2. Bone marrow was reinfused after defrosting in a water bath at 37°C. Bone marrow nucleated cell counts before and after freezing, showed a small relative loss of nucleated cells (35.10 and 31.80x10³µL-1 , respectively). Cyclophosphamide induced neutropenia which was reverted by a granulocyte colony-stimulating factor (G-CSF) capable of stimulating hematopoetic reconstitution. On the day 360 after transplant the patient was found to be in complete remission. This study indicates that autologous BMT in a dog with lymphoma submitted to myelosuppressive chemotherapy was potentially safe and effective.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000200045	
Editor: 	Universidade Federal de Santa Maria	
Relação: 	10.1590/S0103-84782008005000087	
Formato: 	text/html	
Fonte: 	Ciência Rural  v.39 n.2 2009	
Fonte: 	info:eu-repo/semantics/openAccess