Data/hora: 03/06/2024 02:52:38

Provedor de dados: | 69
País: | Chile
Título: | Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
Autores: | Ramírez,Mario A.; Pérez,Herminia I.; Manjarrez,Norberto; Solís,Aida; Luna,Héctor; Cassani,Julia.
Data: | 2008-10-01
Ano: | 2008
Palavras-chave: | 4-chlorobenzophenone; Biocatalysis; Microbial oxidation; Resolution.
Resumo: | Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used: 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000400002
Editor: | Pontificia Universidad Católica de Valparaíso
Formato: | text/html
Fonte: | Electronic Journal of Biotechnology  v.11 n.4 2008