Data/hora: 09/06/2024 03:49:08

Provedor de dados: | 74
País: | Brazil
Título: | Prediction of binding hot spot residues by using structural and evolutionary parameters
Autores: | Higa,Roberto Hiroshi; Tozzi,Clésio Luis.
Data: | 2009-01-01
Ano: | 2009
Palavras-chave: | Hot spots prediction; Protein structure; Hot spots.
Resumo: | In this work, we present a method for predicting hot spot residues by using a set of structural and evolutionary parameters. Unlike previous studies, we use a set of parameters which do not depend on the structure of the protein in complex, so that the predictor can also be used when the interface region is unknown. Despite the fact that no information concerning proteins in complex is used for prediction, the application of the method to a compiled dataset described in the literature achieved a performance of 60.4%, as measured by F-Measure, corresponding to a recall of 78.1% and a precision of 49.5%. This result is higher than those reported by previous studies using the same data set.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000300029
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572009000300029
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.32 n.3 2009
Fonte: | info:eu-repo/semantics/openAccess