Data/hora: 05/06/2024 03:49:21

Provedor de dados: | 74
País: | Brazil
Título: | Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
Autores: | López Soto,Eduardo Javier; Catanesi,Cecilia Inés.
Data: | 2015-06-01
Ano: | 2015
Palavras-chave: | OPRM1; SNPs; A118G; AMOVA; Population genetics.
Resumo: | Several single nucleotide polymorphisms (SNPs) in the Mu Opioid Receptor gene (OPRM1) have been identified and associated with a wide variety of clinical phenotypes related both to pain sensitivity and analgesic requirements. The A118G and other potentially functional OPRM1 SNPs show significant differences in their allele distributions among populations. However, they have not been properly addressed in a population genetic analysis. Population stratification could lead to erroneous conclusions when they are not taken into account in association studies. The aim of our study was to analyze OPRM1 SNP variability by comparing population samples of the International Hap Map database and to analyze a new population sample from the city of Corrientes, Argentina. The results confirm that OPRM1 SNP variability differs among human populations and displays a clear ancestry genetic structure, with three population clusters: Africa, Asia, and Europe-America.
Tipo: | Info:eu-repo/semantics/report
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000200152
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-4757382220140299
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.38 n.2 2015
Fonte: | info:eu-repo/semantics/openAccess