Data/hora: 06/06/2024 19:17:47

Provedor de dados: | 74
País: | Brazil
Título: | Perforin gene PRF1 c.900C&amp;gt; T polymorphism and HIV-1 vertical transmission
Autores: | Zupin,Luisa; Polesello,Vania; Kamada,Anselmo Jiro; Gratton,Rossella; Segat,Ludovica; Kuhn,Louise; Crovella,Sergio.
Data: | 2019-09-01
Ano: | 2019
Palavras-chave: | PRF1; Perforin; HIV-1 susceptibility.
Resumo: | Abstract Perforin-1, a component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of the c.900C &gt; T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. The PRF1 c.900C &gt; T polymorphism was genotyped in 331 children from Zambia using a Taqman probe on a Real Time PCR platform. The PRF1 c.900C &gt; T C/T genotype was more frequent among HIV-1 exposed but non-infected children than in HIV-1 positive cases, and the results were confirmed among children infected during breastfeeding. PRF1 c.900C &gt; T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000400574
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-gmb-2018-0243
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.42 n.3 2019
Fonte: | info:eu-repo/semantics/openAccess