Data/hora: 05/06/2024 19:14:39

Provedor de dados: | 74
País: | Brazil
Título: | Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells
Autores: | Antunes,Lusânia Maria Greggi; Araújo,Maria Cristina Paiva; Dias,Francisca da Luz; Takahashi,Catarina Satie.
Data: | 2005-03-01
Ano: | 2005
Palavras-chave: | CHO; Chromosomal aberrations; Curcumin; Hydrogen peroxide; Mutagenesis.
Resumo: | The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Curcumin combined with H2O2 did not increase the chromosomal aberrations more than expected based on a simple additive effect. In contrast, the combination of curcumin-Fe significantly decreased the total number of chromosomal aberrations and the number of abnormal metaphases. The clastogenicity of curcumin may be related to its pro-oxidant properties and its ability to generate free radicals.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100028
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572005000100028
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.28 n.1 2005
Fonte: | info:eu-repo/semantics/openAccess