Data/hora: 13/06/2024 05:15:55

Provedor de dados: | 74
País: | Brazil
Título: | Interferon lambda 4 (IFNL4) gene polymorphism is associated with spontaneous clearance of HCV in HIV-1 positive patients
Autores: | Alves,Camila Fernanda da Silveira; Grott,Camila Schultz; Lunge,Vagner Ricardo; Béria,Jorge Umberto; Tietzmann,Daniela Cardoso; Stein,Airton Tetelbom; Simon,Daniel.
Data: | 2016-09-01
Ano: | 2016
Palavras-chave: | IFNL4 genotypes; HIV/HCV co-infected patients; Spontaneous clearance.
Resumo: | Abstract Approximately one-third of the individuals infected with human immunodeficiency virus type 1 (HIV-1) are co-infected with hepatitis C virus (HCV). Co-infected patients have an increased risk for developing end-stage liver diseases. Variants upstream of the IFNL3 gene have been associated with spontaneous and treatment-induced clearance of HCV infection. Recently, a novel polymorphism was discovered, denoted IFNL4 ΔG &gt; TT (rs368234815), which seems to be a better predictor of spontaneous clearance than the IFNL4 rs12979860 polymorphism. We aimed to determine the prevalence of the IFNL4 ΔG &gt; TT variants and to evaluate the association with spontaneous clearance of HCV infection in Brazilian HIV-1 patients. The IFNL4 ΔG &gt; TT genotypes were analyzed by polymerase chain reaction followed by restriction digestion in 138 HIV-1 positive patients who had an anti-HCV positive result. Spontaneous clearance of HCV was observed in 34 individuals (24.6%). IFNL4 genotype distribution was significantly different between individuals who had spontaneous clearance and chronic HCV patients (p=0.002). The probability of spontaneous clearance of HCV infection for patients with the IFNL4 TT/TT genotype was 3.6 times higher than for patients carrying the IFNL4 ΔG allele (OR=3.63, 95% CI:1.51-8.89, p=0.001). The IFNL4 ΔG &gt; TT polymorphism seems to be better than IFNL4 rs12979860 to predict spontaneous clearance of the HCV in Brazilian HIV-1 positive patients.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300374
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-GMB-2015-0106
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.39 n.3 2016
Fonte: | info:eu-repo/semantics/openAccess