Data/hora: 10/06/2024 16:21:28

Provedor de dados: | 74
País: | Brazil
Título: | Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity
Autores: | Kabir,Nuzhat N.; Kazi,Julhash U.
Data: | 2011-01-01
Ano: | 2011
Palavras-chave: | EPK; Kinome; APK; Bovine.
Resumo: | Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400010
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572011005000035
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.34 n.4 2011
Fonte: | info:eu-repo/semantics/openAccess