Data/hora: 05/06/2024 00:58:11

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Identification and characterization of polymorphisms at the HSA alpha1-acid glycoprotein (ORM*) gene locus in Caucasians	
Autores: 	Owczarek,Catherine M.; Owczarek,Aleksander L.; Board,Philip G.	
Data: 	2002-01-01	
Ano: 	2002	
Palavras-chave: 	Human alpha1-acid glycoprotein; RFLP; Linkage disequilibrium.	
Resumo: 	Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572002000100004	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.25 n.1 2002	
Fonte: 	info:eu-repo/semantics/openAccess