Data/hora: 05/06/2024 09:16:58

Provedor de dados: | 74
País: | Brazil
Título: | Polymorphism of the catechol-O-methyltransferase gene   in Han Chinese patients with psoriasis vulgaris
Autores: | Gao,Lin; Gao,Lin; Li,Hong; Li,Hong; Li,Kai; Li,Kai; Shen,Zhu; Liu,Ling; Li,Chunying; Zhang,Zhengdong; Liu,Yufeng.
Data: | 2009-01-01
Ano: | 2009
Palavras-chave: | COMT; Gene polymorphism; Genetic susceptibility; Psoriasis.
Resumo: | Psoriasis vulgaris is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase ( COMT )  158  polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. We hypothesized that the  COMT-158  G  &gt;  A  polymorphism was associated with the risk of psoriasis vulgaris in Han Chinese people. In a hospital-based case-control study, 524 patients with psoriasis vulgaris and 549 psoriasis-free controls were studied.  COMT-158 G  &gt;  A  polymorphism was genotyped using the PCR sequence-specific primer (PCR-SSP) technique. We found no statistically significant association between the  COMT-158  allele  A  and the risk of psoriasis vulgaris (p = 0.739 adjusted OR = 1.03; 95% CI = 0.81-1.31). This suggests that the  COMT-158 G  &gt;  A  polymorphism may not contribute to the etiology of psoriasis vulgaris in the Han Chinese population.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100005
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572009005000002
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.32 n.1 2009
Fonte: | info:eu-repo/semantics/openAccess