Data/hora: 09/06/2024 05:41:53

Provedor de dados: | 74
País: | Brazil
Título: | Chromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridization
Autores: | Baruffi,Marcelo Razera; Engel,Edgard Edward; Squire,Jeremy Andrew; Tone,Luis Gonzaga; Rogatto,Silvia Regina.
Data: | 2003-01-01
Ano: | 2003
Palavras-chave: | Comparative genomic hybridization; CGH; Osteosarcoma; Ewing's Sarcoma.
Resumo: | We applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losses at 10p14-pter and gains at 8q22.3-24.1 in OS. Interphase FISH allowed to confirm 8q gain in two cases. A high amplification level of 11q12-qter was detected in one OS. The Ewing's sarcoma showed gain at 1p32-36.1 as the sole chromosome alteration. These studies demonstrate the value of molecular cytogenetic methods in the characterization of recurrent genomic alterations in bone tumor tissue.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000200001
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572003000200001
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.26 n.2 2003
Fonte: | info:eu-repo/semantics/openAccess