Data/hora: 06/06/2024 05:43:27

Provedor de dados: | 74
País: | Brazil
Título: | VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
Autores: | Silva,Ronaldo Celerino da; Alves,Neyla Maria Pereira; Pereira,Jorge José de Souza; Coelho,Antonio Victor Campos; Arraes,Luiz Cláudio; Brandão,Lucas André Cavalcanti; Crovella,Sergio; Silva,Jaqueline de Azevêdo.
Data: | 2019-06-01
Ano: | 2019
Palavras-chave: | VDR; HIV-1; ARVs; SNPs; CD4 recovery.
Resumo: | Abstract Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p &lt; 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300351
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-gmb-2017-0289
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.42 n.2 2019
Fonte: | info:eu-repo/semantics/openAccess