Data/hora: 11/06/2024 14:49:42

Provedor de dados: | 74
País: | Brazil
Título: | Genetic diversity of Toll-like receptor 5 among pig populations
Autores: | Yang,Xiuqin; Li,Haitao; Guan,Qingzhi; Liu,Di.
Data: | 2013-01-01
Ano: | 2013
Palavras-chave: | Porcine; TLR5; SNPs; Haplotype.
Resumo: | The Toll-like receptor 5 (TLR5) recognizes flagellin of Gram-positive and -negative bacteria and plays an important role in the host defense system. Here, we surveyed single nucleotide polymorphisms (SNPs) in the coding sequence of the porcine TLR5 gene in 83 individuals from five pig breeds, these including Chinese local populations and Western commercial pig breeds. A total of 19 medium polymorphic SNPs (0.25 &lt; PIC &lt; 0.5) were identified, three of which were missense mutations that clustered within the extracellular domain of TLR5. One of the non-synonymous SNPs fell within a 228-amino acid region which has been shown to be important for flagellin recognition. Four SNPs were only found with high frequencies in Oriental pig breeds. The 19 SNPs were found in 30 haplotypes, one of which segregated at high frequency in all samples. Compared with Western pig breeds, Chinese local populations had higher genetic diversity and more haplotypes. Tajima's test showed no evidence for deviation from neutrality. The data provide useful information for future genetic marker characterization by means of disease association analysis and/or stimulating the mutation carrier with relevant ligands.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000100006
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572013005000004
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.36 n.1 2013
Fonte: | info:eu-repo/semantics/openAccess