Data/hora: 01/06/2024 01:12:40

Provedor de dados: | 74
País: | Brazil
Título: | Factor XI deficiency in Indian Bos taurus, Bos indicus, Bos taurus x Bos indicus crossbreds and Bubalus bubalis
Autores: | Patel,Rajesh K.; Soni,Kalpesh J.; Chauhan,Jenabhai B.; Singh,Krishna M.; Sambasiva Rao,Krothapalli R.S.
Data: | 2007-01-01
Ano: | 2007
Palavras-chave: | Autosomal recessive disease; Blood coagulation; Buffaloes; Factor XI; Holstein-Friesian dairy cattle.
Resumo: | We investigated the occurrence of Factor XI (FXI) deficiency syndrome in the following Indian dairy animals: Bos taurus Holstein-Friesian and Jersey cattle, Bos indicus Indian cattle breeds, B. taurus x B. indicus crossbreds and the river buffalo Bubalus bubalis. Factor XI deficiency is an autosomal recessive bleeding disorder known to affect Holstein cattle worldwide. A total of 1001 dairy animals, mainly bulls, were genotyped to detect the mutation within exon 12 of the gene encoding for factor XI. Two Holstein bulls were detected as heterozygous (carrier) for FXI deficiency, giving a carrier frequency of 0.6% in Indian Holstein cattle. None of the other cattle or buffalo breeds was found to be a carrier for FXI. Sequence comparison between normal and heterozygous animals revealed that there is a 77 base pair insertion fragment (AT (A)29 TAAAG (A)27 GAATTATTAATTCT) within exon 12 of the FXI gene. Both sequences were submitted to the National Center for Biotechnology Information (NCBI) GenBank and assigned the accession numbers DQ438908 for normal Holstein Friesian animals and DQ438909 for heterozygous Holstein Friesian animals.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400013
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572007000400013
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.30 n.3 2007
Fonte: | info:eu-repo/semantics/openAccess