Data/hora: 05/06/2024 06:27:59

Provedor de dados: | 74
País: | Brazil
Título: | Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans
Autores: | Peralta-Leal,Valeria; Leal-Ugarte,Evelia; Meza-Espinoza,Juan P.; Dávalos-Rodríguez,Ingrid P.; Bocanegra-Alonso,Anabel; Acosta-González,Rosa I.; Gonzales,Enrique; Nair,Saraswathy; Durán-González,Jorge.
Data: | 2012-01-01
Ano: | 2012
Palavras-chave: | SLC6A4 gene; 5-HTTLPR polymorphism; Type 2 diabetes mellitus; Body mass index.
Resumo: | The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy- Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless, logistic regression analysis of the L allele and increased BMI disclosed an association, after adjusting for age, sex and T2DM (p = 0.02, OR 1.74, 95% CI: 1.079-2.808).
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400007
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572012005000048
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.35 n.3 2012
Fonte: | info:eu-repo/semantics/openAccess