Data/hora: 11/06/2024 14:07:42

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Origin of the hemoglobin S gene in a northern Brazilian population: the combined effects of  slave trade and internal migrations	
Autores: 	Pante-de-Sousa,Gabriella; Mousinho-Ribeiro,Rita de Cassia; Santos,Eduardo José Melo dos; Zago,Marco Antonio; Guerreiro,João Farias.	
Data: 	1998-12-01	
Ano: 	1998	
Resumo: 	We analyzed DNA polymorphisms in the &lt;FONT FACE="Symbol"&gt;b&lt;/font&gt;-globin gene cluster of 30 sickle cell anemia patients from Belém, the capital city of the State of Pará, in order to investigate the origin of the &lt;FONT FACE="Symbol"&gt;b&lt;/font&gt;S mutation. Sixty-seven percent of the &lt;FONT FACE="Symbol"&gt;b&lt;/font&gt;S chromosomes were Bantu type, 30% were Benin type, and 3% were Senegal type. The origin of the &lt;FONT FACE="Symbol"&gt;b&lt;/font&gt;S mutation in this population, estimated on the basis of &lt;FONT FACE="Symbol"&gt;b&lt;/font&gt;S-linked haplotypes, contradicts the historical records of direct slave trade from Africa to the northern region of Brazil. Historical records indicate a lower percentage of people from Benin. These discrepancies are probably due to domestic slave trade and later internal migrations, mainly from northeastern to northern regions. Haplotype distribution in Belém did not differ significantly from that observed in other Brazilian regions, although historical records indicate that most slaves from Atlantic West Africa, where the Senegal haplotype is prevalent, were destined for the northern region, whereas the northeast (Bahia, Pernambuco and Maranhão) was heavily supplied with slaves from Central West Africa, where the Benin haplotype predominates.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000400001	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47571998000400001	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.21 n.4 1998	
Fonte: 	info:eu-repo/semantics/openAccess