Data/hora: 09/06/2024 10:49:49

Provedor de dados: | 74
País: | Brazil
Título: | Fine mapping and single nucleotide polymorphism effects estimation on pig chromosomes 1, 4, 7, 8, 17 and X
Autores: | Hidalgo,André M.; Lopes,Paulo S.; Paixão,Débora M.; Silva,Fabyano F.; Bastiaansen,John W.M.; Paiva,Samuel R.; Faria,Danielle A.; Guimarães,Simone E.F.
Data: | 2013-01-01
Ano: | 2013
Palavras-chave: | Bayesian LASSO Piau breed pig genetics; QTL.
Resumo: | Fine mapping of quantitative trait loci (QTL) from previous linkage studies was performed on pig chromosomes 1, 4, 7, 8, 17, and X which were known to harbor QTL. Traits were divided into: growth performance, carcass, internal organs, cut yields, and meat quality. Fifty families were used of a F2 population produced by crossing local Brazilian Piau boars with commercial sows. The linkage map consisted of 237 SNP and 37 microsatellite markers covering 866 centimorgans. QTL were identified by regression interval mapping using GridQTL. Individual marker effects were estimated by Bayesian LASSO regression using R. In total, 32 QTL affecting the evaluated traits were detected along the chromosomes studied. Seven of the QTL were known from previous studies using our F2 population, and 25 novel QTL resulted from the increased marker coverage. Six of the seven QTL that were significant at the 5% genome-wide level had SNPs within their confidence interval whose effects were among the 5% largest effects. The combined use of microsatellites along with SNP markers increased the saturation of the genome map and led to smaller confidence intervals of the QTL. The results showed that the tested models yield similar improvements in QTL mapping accuracy.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000400009
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572013000400009
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.36 n.4 2013
Fonte: | info:eu-repo/semantics/openAccess