Data/hora: 02/06/2024 09:41:00

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Beyond retrovirus infection: HIV meets gene therapy	
Autores: 	Silva,Flávia Helena da; Dalberto,Tiago Pires; Nardi,Nance Beyer.	
Data: 	2006-01-01	
Ano: 	2006	
Palavras-chave: 	HIV; MLV; Retrovirus; Lentivirus; Gene therapy.	
Resumo: 	The human immunodeficiency virus (HIV) is classified as a retrovirus because of its RNA genome and the fact that it requires reverse transcriptase to convert it into DNA. This virus belongs to the lentivirinae subfamily and is able to infect quiescent cells but is better known for its association with acquired immunodeficiency syndrome (AIDS) and can be described as one of the most effective vectors for gene transfer. Biosafety concerns are present whenever viral vectors are employed but are particularly pertinent to the development of HIV-based vectors. Insertional mutagenesis and the production of new replication-competent viruses (RCV) have been pointed to as major problems, but experimental data have shown that safe protocols can be developed for their production and application. Virological, evolutionary, immunological and cell biology studies must be conducted jointly to allow the clinical use of HIV vectors. This review will focus on the general properties, production and applications of retrovectors in gene therapy, with particular emphasis on those based on HIV systems.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000200027	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572006000200027	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.29 n.2 2006	
Fonte: 	info:eu-repo/semantics/openAccess