Data/hora: 09/06/2024 13:48:55

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Matrix metalloproteinase gene polymorphisms in patients with coronary artery disease	
Autores: 	Dalepiane,Vanessa L.N.; Silvello,Daiane N.; Paludo,Crislaine A.; Roisenberg,Israel; Simon,Daniel.	
Data: 	2007-01-01	
Ano: 	2007	
Palavras-chave: 	Atherosclerosis; Coronary artery disease; Gene polymorphisms; Matrix metalloproteinases.	
Resumo: 	Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis, the pathology underlying the majority of coronary artery disease (CAD). In this study we tested the hypothesis that polymorphic variation in the MMP genes influences the risk of developing atherosclerosis. We analyzed functional polymorphisms in the promoter of the MMP-1, MMP-3, MMP-9 and MMP-12 genes in 183 Brazilian Caucasian individuals submitted to coronary angiography, of which 67 (37%) had normal coronary arteries (control group) and 116 (63%) had CAD (CAD patient group). The -1607 1G/2G MMP-1, -1171 5A/6A MMP-3, -1562 C/T MMP-9, -82 A/G MMP-12 polymorphisms were analyzed by PCR followed by restriction digestion. No significant differences were observed in allele frequencies between the CAD patients and controls. Haplotype analysis showed no differences between the CAD patients and controls. There was a significant difference in the severity of CAD, as assessed by the number of diseased vessels, in MMP-1 1G/1G homozygous individuals and in those homozygous for the 6A allele of the MMP-3 polymorphism. However, multivariate analysis showed that diabetes mellitus was the only variable independently associated with CAD severity. Our findings indicated that MMP polymorphisms have no significant impact on the risk and severity of CAD.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400001	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572007000400001	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.30 n.3 2007	
Fonte: 	info:eu-repo/semantics/openAccess