Data/hora: 09/06/2024 14:57:27

Provedor de dados: | 74
País: | Brazil
Título: | Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
Autores: | Zhang,Xinju; Jin,Lei; Wu,Zhiyuan; Ma,Weizhe; Chen,Yuming; Chen,Gang; Wang,Lixin; Guan,Ming.
Data: | 2018-09-01
Ano: | 2018
Palavras-chave: | Rs9263726; HLA-B*58:01; Allopurinol hypersensitivity reaction; Tag SNP.
Resumo: | Abstract The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an efficient indicator of potential allopurinol hypersensitivity syndrome. In this study, rs9263726 and HLA-B*58:01 were detected in all samples. For samples of individuals whose rs9263726 genotypes were not consistent with HLA-B*58:01, we did high-resolution typing of HLA-B gene to further confirm the correlation of rs9263726 genotype and special HLA-B alleles. We confirmed that the linkage disequilibrium between rs9263726 and HLA-B*58:01 was more significant in the Han ethnic group (r2=0.886, D’=1.0) than in the Tibet and Hui ethnic groups (for Tibetan, r2=0.606, D’=0.866; for Hui, r2=0.622, D’=0.924). For Han Chinese, samples with the GG genotype of rs9263726 did not carry HLA-B*58:01, while AA genotype samples were homozygous carriers of HLA-B*58:01. However, GA genotype samples of rs9263726 required a more sophisticated HLA-B genotyping assay before it was possible to identify whether they were HLA-B*58:01 carriers or not. For Tibetan and Hui, the linkage disequilibrium between rs9263726 and HLA-B*58:01 was not significant. Therefore, rs9263726 cannot replace HLA-B*58:01 in these two groups.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400578
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-gmb-2017-0258
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.41 n.3 2018
Fonte: | info:eu-repo/semantics/openAccess