Data/hora: 09/06/2024 01:49:14

Provedor de dados: 	74	
País: 	Brazil	
Título: 	Evaluation of the genotoxic potential of the Hypericum brasiliense (Guttiferae) extract in mammalian cell system in vivo	
Autores: 	Espósito,Anderson Victorino; Pereira,Danielli Maria Vieira; Rocha,Leandro Machado; Carvalho,José Carlos Tavares; Maistro,Edson Luis.	
Data: 	2005-03-01	
Ano: 	2005	
Palavras-chave: 	Hypericum brasiliense; Micronucleus test; Chromosome aberrations.	
Resumo: 	Plants of the genus Hypericum, long used in folk medicine, contain active compounds which present, anti-septic, diuretic, digestive, expectorant, vermifugal, anti-depressive and other properties. The possible clastogenic effect of a H. brasiliense extract was tested in vivo on the bone marrow cells of Wistar rats. The extract was administered by gavage at doses of 50, 150 and 300 mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment for micronucleus (MN) and chromosome preparations. H. brasiliense extract did not induce statistically significant increases in the average numbers of MN or chromosome aberrations in the test systems employed.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100026	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572005000100026	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.28 n.1 2005	
Fonte: 	info:eu-repo/semantics/openAccess