Data/hora: 16/06/2024 04:47:02

Provedor de dados: | 74
País: | Brazil
Título: | MTHFR , prothrombin and Factor V gene variants in Turkish patients   with coronary artery stenosis
Autores: | Caner,Müge; Bircan,Rifat; Sevinç,Deniz; Benli,Fehime; Güney,A. Ilter; Kurtoglu,Nuri.
Data: | 2008-12-01
Ano: | 2008
Palavras-chave: | Genetic polymorphism; Coronary disease; MTHFR gene; Prothrombin gene; Factor V gene.
Resumo: | Many epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase ( MTHFR  C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease,  i.e. , significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500006
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/S1415-47572008005000023
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.31 n.4 2008
Fonte: | info:eu-repo/semantics/openAccess