Data/hora: 10/06/2024 13:39:27

Provedor de dados: | 74
País: | Brazil
Título: | DNA replication stress: oncogenes in the spotlight
Autores: | Primo,Luiza M. F.; Teixeira,Leonardo K.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | Cancer; Cell cycle; DNA replication; Oncogene; Replication stress.
Resumo: | Abstract Precise replication of genetic material is essential to maintain genome stability. DNA replication is a tightly regulated process that ensues faithful copies of DNA molecules to daughter cells during each cell cycle. Perturbation of DNA replication may compromise the transmission of genetic information, leading to DNA damage, mutations, and chromosomal rearrangements. DNA replication stress, also referred to as DNA replicative stress, is defined as the slowing or stalling of replication fork progression during DNA synthesis as a result of different insults. Oncogene activation, one hallmark of cancer, is able to disturb numerous cellular processes, including DNA replication. In fact, extensive work has indicated that oncogene-induced replication stress is an important source of genomic instability in human carcinogenesis. In this review, we focus on main oncogenes that induce DNA replication stress, such as RAS, MYC, Cyclin E, MDM2, and BCL-2 among others, and the molecular mechanisms by which these oncogenes interfere with normal DNA replication and promote genomic instability.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200301
Editor: | Sociedade Brasileira de Genética
Relação: | 10.1590/1678-4685-gmb-2019-0138
Formato: | text/html
Fonte: | Genetics and Molecular Biology  v.43 n.1 suppl.1 2020
Fonte: | info:eu-repo/semantics/openAccess