Data/hora: 09/06/2024 07:41:53

Provedor de dados: 	77	
País: 	Chile	
Título: 	p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study	
Autores: 	Sá,Cláudia T.; Fonseca,Linaena M. S.; Cardoso,Sérgio V.; Aguiar,Maria Cássia F.; Carmo,Maria Auxiliadora V. do.	
Data: 	2006-06-01	
Ano: 	2006	
Palavras-chave: 	P53 protein; Immunohistochemistry; Oral squamous cell carcinoma (OSCC).	
Resumo: 	p53 alterations have been implicated in oral carcinogenesis process. Squamous cell carcinoma is the most common malignancy of the oral cavity, the tongue being the most frequent affected site. The aim of this study was to compare p53 immunoexpression in 43 samples of oral SCC from 5 different anatomical sites: tongue, floor of the mouth, alveolar ridge/gingiva, retromolar region and other regions of the oral cavity. Thirty-three lesions (76,8%) showed positivity for p53 (mean index of 48,37%). No statistically significant differences were found between p53 expression and the different oral sites analyzed. Similarly, no differences were found when comparing tongue lesions with the remaining sites. These results suggest that it might not exist any difference among oral cavity anatomical sites in relation to p53 immunoexpression. Moreover, mechanisms other than p53 alterations in squamous cell carcinomas of the tongue may be of relevance for the higher tumour aggressiveness found in this anatomical site	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300018	
Editor: 	Sociedad Chilena de Anatomía	
Formato: 	text/html	
Fonte: 	International Journal of Morphology  v.24 n.2 2006