Data/hora: 06/06/2024 17:14:27

Provedor de dados: | 77
País: | Chile
Título: | Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model
Autores: | Albuquerque-Júnior,Ricardo Luiz Cavalcanti de; Barreto,André Luiz Santos; Pires,Jônatas Almeida; Reis,Francisco Prado; Lima,Sônia Oliveira; Ribeiro,Maria Amália Gonzaga; Cardoso,Juliana Cordeiro.
Data: | 2009-12-01
Ano: | 2009
Palavras-chave: | Propolis; Wound healing; Occlusive dressings; Type-I collagen.
Resumo: | Propolis, an apitherapic product widely employed in natural medicine, presents various biological properties, such as bactericidal and anti-inflammatory activities, but only few reports have looked at the Brazilian red propolis variety. Collagen films have been employed to improve wound healing and some studies have investigated the effect of natural products incorporated into these films. Thus, the aim of this study was to analyze the effect of collagen-based films containing red propolis on wound healing. Therefore, wounds performed in the back of rats were dressed with collagen-based films (G2), and collagen-based films containing red propolis (G3); undressed worked as control (G1). After 3, 7 and 14 days the animals were euthanized, and the wounds were microscopically evaluated. In 7 days, G3 showed switch of the inflammatory profile from acute into chronic, increased plasma cells differentiation, replacement of Type-III for type-I collagen fibers, and better architectural organization of those fibers. Furthermore, a slight tendency for a better epithelization was verified in G3, but it was not statistically significant. Also in 7 days, the microvessels count was higher in G1 than in G2 (p=0.000) and G3 (p=0.001), but similar between the last groups (p=0,15), whereas the microvessels perimeter was higher in G1 than in G2 (p=0.000) and G3 (p=0.002), but equivalent in G2 and G3 (p=0.175) in 14 days. In conclusion, the incorporation of Brazilian red propolis into collagen-based films was able to improve wound healing, probably by modulating the dynamics of the inflammatory evolution and collagen deposition process.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400025
Editor: | Sociedad Chilena de Anatomía
Formato: | text/html
Fonte: | International Journal of Morphology  v.27 n.4 2009