Data/hora: 17/06/2024 15:41:29

Provedor de dados: | 77
País: | Chile
Título: | A Common 34C&gt;G Variant at the Peroxisome Proliferator-Activated Receptor &amp;#947;2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls
Autores: | Guzmán,Neftalí; Erices,Leonardo; Valdés,Patricio; Salazar,Luis A.
Data: | 2007-12-01
Ano: | 2007
Palavras-chave: | Polycystic ovary syndrome; Peroxime proliferator-activated receptor; Prol2Ala polymorphism.
Resumo: | The 34C&gt;G (Prol2Ala) polymorphic variant of the peroxisome proliferator-activated receptor-&amp;#947;2 (PPAR-&amp;#947;2) gene has been associated with polycystic ovary syndrome (PCOS). However, the results between populations are contradictory. Thus, in the present study was investigated the possible association between 34C&gt;G polymorphism at the PPAR-&amp;#947;2 gene and PCOS in Chilean women. A total of 50 unrelated women (29.1 + 8.1 years) with diagnosis of PCOS and 75 healthy controls (29.3+ 9.3 years) were included in this study. Serum lipids, glucose and uric acid levels were determined by enzymatic-colorimetric methods. The 34C&gt;G variant in the PPAR-&amp;#947;2 gene was analyzed by PCR-RFLP. Women with PCOS exhibited a higher levels of glucose, total cholesterol, triglycerides, LDL-C and uric acid, and lower HDL-C levels than controls (p &lt;0.05). The frequency of the 34G alíele was 9% in PCOS patients and 12% in control women (p = 0.589). The odds ratio for PCOS associated with 34G alíele was 0.73 (95% CI = 0.31 - 1.69) confirming the absence of association. We conclude that the 34C&gt;G polymorphism of the PPAR-&amp;#947;2 gene is not related to PCOS in Chilean women
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400030
Editor: | Sociedad Chilena de Anatomía
Formato: | text/html
Fonte: | International Journal of Morphology  v.25 n.4 2007