Data/hora: 17/06/2024 12:58:38

Provedor de dados: 	77	
País: 	Chile	
Título: 	Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus	
Autores: 	Pereira Alves,Angela Maria; de Paula,Anderson Luiz; Moreira,Cassio Rafael; Ferrari,Fernanda; Coelho Leal,Jean Paulo; Hatoum,Ualid Saleh; Vieira Silva,Helaine Maruska; Belato Alves,Eder Paulo; de Miranda Neto,Marcilio Hubner; Galvanini,Paulo Alexandre.	
Data: 	2017-03-01	
Ano: 	2017	
Palavras-chave: 	Diabetes mellitus; Enteric neurons; Quercetin; NADH diaphorase.	
Resumo: 	The effects of quercetin supplementation in NADH-diaphorase positive (NADH-d) neurons of streptozotocin-induced diabetic rats was carried in this study. Fifteen male rats were divided into three groups: normoglycemic (N), diabetic (D) and diabetic supplemented with quercetin (DQ). Whole mount preparations of the muscular layer of the ileum underwent NADH-d histochemistry for evidencing the NADH-d neuronal subpopulation. Quantitative analyzes were performed on 30 random fields, and morphometric analyzes in 100 neuronal bodies and nuclei per animal. The supplementation promoted a 44 % reduction in the neuronal density in D group when compared to N group (p &lt;0.001); a 24.5 % reduction was observed in the DQ group when compared to N (p &lt;0.01). Animals in D group presented an 18.7 % increase in the cell body areas of myenteric neurons when compared to N (p &lt;0.001); DQ group showed a 14.2 % decrease in neuronal areas when compared to D (p &lt;0.01); the nuclear area were similar among the three groups. We conclude that quercetin supplementation was positive for animals with diabetes mellitus.	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100039	
Editor: 	Sociedad Chilena de Anatomía	
Formato: 	text/html	
Fonte: 	International Journal of Morphology  v.35 n.1 2017