Data/hora: 07/06/2024 03:43:42

Provedor de dados: | 77
País: | Chile
Título: | Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition
Autores: | Zuanassi Macari,Marcelo; Misael Cavenaghi,Fabiano; Chinali Komesu,Marilena; Orive Lunardi,Laurelúcia; Sala,Miguel Angel; Novaes Júnior,Arthur Belém; Grisi,Márcio Fernando de Moraes; Taba Júnior,Mário; Scombatti de Souza,Sérgio Luiz.
Data: | 2005-01-01
Ano: | 2005
Palavras-chave: | Undernourishment; Wound healing; Defense cells.
Resumo: | Undernutrition in early life is associated with a number of acute and chronic sequelae, and recovering is a controversial issue. Even if undernutrition in Brazil is declining, studies have shown that about 31% of brazilian children still present severe or moderate malnutrition. The present study goal was to induce early malnutrition in rats and observe short- (undernourished) and long-term (after recovered) effects on defense cells involved in wound healing. Undernutrition was produced by separating the pups from the mother for 10 hours/day during the suckling period (21 days after birth). As controls were used rats at same age not submitted to suckling restriction. Undernutrition and recovering states were assessed by body weight. Skin wounds were made on the shaved backs of all, undernourished, recovered and their controls, under tribromoethanol anesthesia. Aninals were sacrificed 1, 3, 7 and 14 days after surgery and the tissues were properly prepared and observed under light microscopy. Our results showed that: 1) neutrophils, lymphocytes and macrophages couting in healing area were lower in undernourished and in recovered animals as compared with their controls; 2) there were a basal deficiency in lymphocytes and macrophages numbers in recovered animals but not in those acutelly undernourished. These results allow us to conclude that post-nattally undernourished animals submitted to a nutritional rescue time showed a complete recovery in physical weight, but in spite of the physical recovery, the wound healing showed less defense cell density in healing areas suggesting long-term sequelae of early undernutrition
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000100005
Editor: | Sociedad Chilena de Anatomía
Formato: | text/html
Fonte: | International Journal of Morphology  v.23 n.1 2005