Data/hora: 01/06/2024 08:37:19

Provedor de dados: | 79
País: | Brazil
Título: | Sub-lethal injection of honeybee venom decreased the levels of endogenously present substances in organs of mice
Autores: | LIPPS,B. V.
Data: | 2002-01-01
Ano: | 2002
Palavras-chave: | Honeybee venom; Adenosine deaminase; Collagen; Histamine; IgE; Myoglobin; Nerve growth factor.
Resumo: | Pharmacological substances such as adenosine deaminase (ADA), collagen, histamine, IgE, myoglobin, and nerve growth factor (NGF) are endogenously present in animals. Research from this laboratory reported decreased levels of ADA, histamine, IgE, and NGF in organs of mice injected with sub-lethal doses of cobra venom. The goal of this research is to observe the levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs of mice injected with venom from the bee Apis mellifera. Adult Balb/c female mice IM injected with half lethal dose of bee venom were sacrificed after 2 and 8 hours for removal of organs. The homogenates of the organs were assayed by ELISA for ADA, collagen, histamine, IgE, myoglobin, and NGF using respective antisera. Organs from mice injected with PBS were used as controls. It was observed that there were decreased levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs after 2 h and tremendous decrease after 8 h. This is the first report showing the pharmacokinetics of ADA, collagen, histamine, IgE, myoglobin, and NGF as consequence of honeybee envenomation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000200006
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
Relação: | 10.1590/S0104-79302002000200006
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins  v.8 n.2 2002
Fonte: | info:eu-repo/semantics/openAccess