Data/hora: 09/06/2024 04:34:06

Provedor de dados: | 80
País: | Brazil
Título: | Snake venom galactoside-binding lectins: a structural and functional overview
Autores: | Sartim,Marco A.; Sampaio,Suely V.
Data: | 2015-01-01
Ano: | 2015
Palavras-chave: | Snake venom; C-type lectin; Galactoside-binding protein; Carbohydrate recognition domain; Glycoconjugates; Inflammatory response; Antitumor activity; Bactericidal activity; Mitogenic activity; Platelet aggregation.
Resumo: | AbstractSnake venom galactoside-binding lectins (SVgalLs) comprise a class of toxins capable of recognizing and interacting with terminal galactoside residues of glycans. In the past 35 years, since the first report on the purification of thrombolectin from Bothrops atrox snake venom, several SVgalLs from Viperidae and Elapidae snake families have been described, as has progressive improvement in the investigation of structural/functional aspects of these lectins. Moreover, the advances of techniques applied in protein-carbohydrate recognition have provided important approaches in order to screen for possible biological targets. The present review describes the efforts over the past 35 years to elucidate SVgalLs, highlighting their structure and carbohydrate recognition function involved in envenomation pathophysiology and potential biomedical applications.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100213
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1186/s40409-015-0038-3
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.21 2015
Fonte: | info:eu-repo/semantics/openAccess