Data/hora: 06/06/2024 10:31:57

Provedor de dados: | 80
País: | Brazil
Título: | Hemolitic action of Naja naja atra cardiotoxin on erythrocytes from different animals
Autores: | Troiano,J. C.; Gould,E. G.; Gould,I.
Data: | 2006-01-01
Ano: | 2006
Palavras-chave: | Hemolysis; Cobra; Venom; Erythrocytes; Animals.
Resumo: | A comparative study on the sensitivity of erythrocytes from different vertebrate species (avian, mammalian and reptilian) to the hemolytic action caused by cardiotoxin isolated from Naja naja atra venom was carried out. Cardiotoxin was able to induce direct hemolysis in washed erythrocytes from several animals, except for llama. The EC50 values from hemolysis of the most sensitive (cat) and the most resistant (snake) animal varied approximately tenfold. According to the cell behavior, it was possible to characterize four types of behavior: The first was observed in cat, horse and human cells; the second in rat, rabbit and dog erythrocytes; and the third only in llama erythrocytes, which were resistant to cardiotoxin concentrations up to 300 µg/ml. Finally, avian and reptilian erythrocytes were more resistant to cardiotoxin III-induced hemolysis than those of the mammalian species.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100004
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1590/S1678-91992006000100004
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.12 n.1 2006
Fonte: | info:eu-repo/semantics/openAccess